Research

RESEARCH

The Labrador Retriever Club, Inc. encourages the use of all validated diagnostic modalities for the detection of inherited genetic problems in the Labrador Retriever Club. The Labrador Retriever Club support the use of OFA  Data Bases, Penn Hip, CERF and other individual tests such as the test for CNM1, the Optigen tests for the prcd form of PRA in the Labrador Retriever, and the new test for EIC.

The Optigen test, while a valid and worthwhile test, is not a substitute for the CERF examination.  The Labrador Retriever Club continues to recommend annual CERF examinations in all breeding Labradors. Inclusion in the CHIC program requires examination for hips, elbow and eyes with open disclosure of the results. Additional testing is encouraged but is not required for a CHIC certificate to be issued.

Exercise Induced Collapse (EIC)

I am pleased to announce that Erika Werne from the AKC Canine Health Foundation has confirmed to me that the gene has been found  for EIC.

The researchers have applied for a patent and will be offering a commercial test soon. Hopefully this test will be priced in the same price area as the test for CNM($65.00).

The University of Minnesota who will initially offer the test does not have a website regarding this opportunity but hopes to by March of 2008.

I have approved an article describing this test written by Lee Foote which will appear in the AKC Gazette (April).

As a group we should take pride in the fact that we financially supported this research. Obviously additional reserach dollars are not needed for this work so I will continue to review other proposals.

Fran Smith DVM, LRC Genetics Defects Committee

A test to determine EIC clear, affected or carrier Labrador Retrievers should be available at the University of Minnesota by May or June of 2008.

 
Research Funding

The following grant proposals have been reviewed and approved for funding from our donor advised fund at the Canine health Foundation. Total money deducted from our donor advised fund will be $24,500. 

The grants are:

  • #613
    The prognostic Significane of Chromosome Aneuplopidy in  Canine Lymphoma
     Matthew Breen, No Carolina State
    $5000
     
  • #768
    CollabarativeStudy by Veterinary Oncologists, 
    Pathologists and Diagnostic Laboratories to Enhance the Detection, 
    Diagnosis and Treatment of Canine Lymphoma- Ted Valli University of Illinois
    $500
     
  • #741 
    Polymicrobial Bacteria-Associated Inflammatory Stifle Arthritis/Degenerative Cranial Cruciate Ligament rupture in Dogs
    Peter Muir University of Wisconsin
    $10,000
     
  • #833
    A Synoviocyte Phenotypes and Antibodies Associated with Partially Disrupted Cranial Cruciate Ligaments
    Mandi Lopez Louisiana State University
    $1000
     
  • #1037
    A The Accuracy of Magnetic Resonance Imaging (MRI)  for diagnosis of Meniscal Lesions in Dogs with Naturally  Occurring Cranial Cruciate Ligament Insuffiiciency
    Tisha Harper Virginia-Maryland RCVM
    $1000
     
  • #1003
    A Variation in Thyroid Hormone Concentration and Thyroglobulin Autoantibody Status with Stage of the Canine Estrous Cycle
    Rebecca Davies  University of Minnesota
    $1000
     
  • #1018
    A Comparative Gene Discovery for Canine Cryptorchisim 
    Max Rothschild- Iowa Sate University
    $1000
     
  • #779   
    Characterization of the Canine Y Chromosome Identifying Genes That Cause Male Infertility
    William Murphy Texas A & M
    $5000

Please also note that the EIC test will be offered at the University of Minnesota but is currently unavaiable until certain publications are complete and the patent process is further along. Dr. Michelson and Patterson have  promised me a press release for the the Newsletter and Field Trial News outlining the specifics. Of note, they have found the gene at equal incidence in both bench and field pedigrees.

I also received progress reports onf Grant 632 - MicroRNA's and Canine Lymphoma - Williams Kisseberth which has made satisfactory progress andGrant 593A Mapping Genes Associated with Canine Hemangiosarcoma - Kerstin Lindblad-Toh - which has made outstanding progress. We should be proud of our contributions.